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Thank you for your interest in the GLOW trial!

This trial is testing whether faecal microbiota transplant, or FMT, could be a safe and practical treatment for people with Long COVID.

Below is an overview of the trial and what it involves. Please take your time to read through this information and feel free to discuss it with a friend or family member if needed.

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What is Long COVID?

Long COVID is when someone continues to feel unwell for weeks or months after having COVID-19. This can mean their original symptoms don't go away, or they might develop new symptoms that affect their daily life.

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What is FMT?

FMT is the transfer of gut bacteria from a carefully screened donor into someone who is unwell, with the aim of changing the gut environment in a way that may help reduce symptoms and support recovery.

In this study, it will be given as a rectal enema (a liquid given through the bottom). FMT is approved in Australia for other conditions, but not for Long COVID.

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What does this study involve?

Five in-person visits at University Hospital Geelong
- Three baseline visits to receive the enemas (Week 1)
- Two follow-up visits (Week 4 and Week 8)
Samples collected: blood, urine, stool
Online assessments to complete at home
Wearing a Garmin watch to track your activity, sleep, and heart rate

You can keep taking your usual medications or supplements. Taking part in this study is free, and you will be reimbursed $20 for each in-person visit.

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What type of study is this?

This is a randomised clinical trial. This means you have a 50% chance of receiving either:

FMT (the active treatment)
Placebo (a treatment with no active ingredients)

Neither you nor the study team will know which treatment you get (this is called "blinding").

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Why are we doing this?

We want to find out if FMT can be given in a way that is safe, acceptable, and practical for people with Long COVID. This will help us decide if a larger trial is worth doing in the future.

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Am I eligible?

Please take a moment to answer the question below to see if you might be eligible for the GLOW trial. There are no right or wrong answers - just answer as honestly as you can.

If your answers suggest you may be eligible, we'll invite you for a full screening appointment to confirm your eligibility before enrolling you in the trial.

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Thank you for your interest in the GLOW trial!

If you are having any issues completing the pre-screening survey, or have any questions regarding your eligibility, please contact the GLOW Team on (03) 4215 3078 or email us at CTUClinicalTrialsUnit@barwonhealth.org.au.

You have selected an option that triggers this survey to end right now.

To save your responses and end the survey, click the 'End Survey' button below. If you have selected the wrong option by accident and/or wish to return to the survey, click the 'Return and Edit Response' button.